Which Lash Serums Contain Prostaglandins (And Which Don’t!)

If you’re in the market for a lash serum, you probably noticed that some of them contain prostaglandins while others don’t. Prostaglandins serums are effective but can cause some side effects, some of which are permanent.

Thankfully, peptides-based serums are an excellent alternative with less chance for side effects.

In this article, I compiled a list of popular eyelash growth serums and analyzed the ingredients to know if they contained prostaglandins or not. That way, you can choose the product that’s right for you!

Let’s dive into it!

Disclaimer: Although I have been doing eyelash enhancement treatments for years, I am not a doctor. All content and information in this post are for informational and educational purposes only and do not constitute medical advice. Always seek the advice of your own Medical Provider regarding any questions or concerns you have about your specific health before implementing any recommendations or suggestions from our Website.

Why You Should Care About Prostaglandins

Latisse is the only FDA-approved eyelash growth serum on the market. The active ingredient is bimatoprost, a type of prostaglandin.

Now, because of the extensive clinical studies that were done, we know that Latisse is effective at growing your eyelashes, but we also know that it comes with possible side effects.

Therefore, any other eyelash serum that uses a prostaglandin analog compound is subject to the same side effects.

The most common adverse events from prostaglandin lash serums are:

• Itchy eyes
• Dryness
• Darkening of the skin around the eye
• Darkening of the eye color
• Eye Inflammation
• Swelling of the retina
• Fat atrophy around the eye

So what’s the problem?

Except for Latisse, prostaglandin-based lash growth serums are sold as cosmetics and are not subject to FDA approval like a medication would.

This means that the companies don’t have to do extensive safety testing like they would for a drug.

That’s a big issue.

In reality, these products should be treated as medication since they use an active ingredient.

That’s why deciding whether or not you are okay with the potential side effects of a prostaglandin analog eyelash growth serum is so important.

Lash Serums With Prostaglandins

Eyelash Serum	Contains Prostaglandin?	Active Ingredient	Ingredient List
Latisse	Yes	Bimatoprost	Active ingredient: bimatoprost Inactive ingredients: benzalkonium chloride; sodium chloride; sodium phosphate, dibasic; citric acid; and purified water. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life ranges from 6.8 – 7.8. Source: https://www.latisse.com/pdfs/LatisseProductInformation.pdf
GrandeLASH	Yes	Isopropyl Cloprostenate	Water/Aqua/Eau, Panthenol, Glycerin, Sodium Citrate, Leuconostoc/Radish Root Ferment Filtrate, Alanine, Alcohol, Aloe Barbadensis Leaf Juice, Arctostaphylos Uva URSI Leaf Extract, Arginine, Aspartic Acid, Calcium Gluconate, Caprylyl Glycol, Chamomilla Recutita (Metricaria) Flower Extract, Ethylhexylglycerin, Gluconolactone, Glycine, Hexylene Glycol, Histidine, Honey Extract/Mel/Extrait de Miel, Hydrolyzed Glycosaminoglycans, Hydrolyzed Yeast Extract, Hydroxyethylcellulose, Isoleucine, Isopropyl Cloprostenate, Magnesium Ascorbyl Phosphate, Panax Ginseng Root Extract, PCA, Phenylalanine, Polysorbate 20, Proline, Propylene Glycol, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tocopheryl Acetate, Triethanolamine, Tussilago Farfara (Coltsfoot) Leaf Extract, Valine, Vitis Vinifera (Grape) Seed Extract, Phenoxyethanol, Sodium Benzoate, Sodium Metabisulfite Source: https://grandecosmetics.com/products/grandelash-md
R + F Lash Boost	Yes	Isopropyl Cloprostenate	Water/​Aqua/​Eau, Butylene Glycol, Hydroxyethylcellulose, Keratin, Hydrolyzed Keratin, Biotin, Sodium Hyaluronate, Isopropyl Cloprostenate, Octapeptide-2, Allantoin, Panthenol, Copper Tripeptide-1, Pantethine, Polypeptide-23, Cucurbita Pepo (Pumpkin) Seed Extract, Glycerin, Sea Water, Malus Domestica Fruit Cell Culture Extract, Hydrolyzed Glycosaminoglycans, Prunus Amygdalus Dulcis (Sweet Almond) Fruit Extract, Backhousia Citriodora Leaf Oil, Dipotassium Glycyrrhizate, Rhizobian Gum, Styrene/​Acrylates/​Ammonium Methacrylate Copolymer, Xanthan Gum, PVP, Lecithin, PEG-12 Dimethicone, Alcohol Denat, Chlorphenesin, Phenoxyethanol, Sorbic Acid, Sodium Hydroxide Source: https://www.rodanandfields.com/en-us/shop/r-f-lash-boost/p/ENHLSH01
RevitaLash	Yes	Dechloro Dihydroxy Difluoro Ethylcloprostenolamide	Aqua/Water/Eau, Glycerin, Biotin, Cellulose Gum, Phenoxyethanol, Chlorphenesin, Disodium Phosphate, Phosphoric Acid, Dechloro Dihydroxy Difluoro Ethylcloprostenolamide, Butylene Glycol, Calendula Officinalis Extract, Panax Ginseng Extract, Serenoa Serrulata Extract, Camellia Sinensis Extract, Swertia Japonica Extract, Triticum Vulgare Germ Protein, Pentylene Glycol, Biotinoyl Tripeptide-1, Octapeptide-2 Source: https://www.revitalash.com/products/revitalash-advanced-eyelash-conditioner
neuLASH	Yes	Isopropyl Cloprostenate	Water (Aqua), Butylene Glycol, Hydroxyethylcellulose, Rhizobian Gum, Sodium Hyaluronate, Biotin, Panthenol, Pantethine, Allantoin, Cucurbita Pepo (Pumpkin) Seed Extract, Dipotassium Glycyrrhizate, Sea Water (Maris Aqua), Octapeptide-2, Copper Tripeptide-1, sh-Polypeptide-1, Glycine Soja (Soybean) Oil, Glycerin, Hydrogenated Lecithin, Alcohol, Isopropyl Cloprostenate, Phenoxyethanol, Chlorphenesin, Sorbic Acid, Sodium Hydroxide, Potassium Sorbate, Citric Acid, Disodium EDTA, Sodium Oleate, Dicalcium Phosphate Source: https://skinresearchlabs.com/products/neulash-lash-enhancing-serum
RapidLash	Yes	Isopropyl Cloprostenate	Water (Aqua), Butylene Glycol, HydroxyethylcelIulose, Octapeptide-2, Copper Tripeptide-1, Biotin, Panthenol, sh-Polypeptide-1, Glycine Soja (Soybean) Oil, Cucurbita Pepo (Pumpkin) Seed Extract Sodium Hyaluronate, Hydrolyzed, Glycosaminoglycans, Allantoin, Dipotassium Glycyrrhizate, Pantethine, Hydrogenated Lecithin, Sea Water (Maris Aqua), Glycerin, Rhizobian Gum, Disodium Phosphate, Polysorbate 60, Sodium Phosphate, Ethyl Acetate, Sodium Oleate, Sodium Hydroxide, Citric Acid, Alcohol Denat., lsopropyl Cloprostenate, Phenoxyethanol, Chlorphenesin, Sorbic Acid, Potassium, Sorbate, Disodium EDTA Source: https://rapidlash.com/products/rapidlash-eyelash-serum
Babe Lash	Yes	Isopropyl Cloprostenate	Aqua (Water), Glycerin, Panthenol, Sodium Citrate, Leuconostoc / Radish Root Ferment Filtrate, Alanine, Alcohol, Arbutin, Arginine, Aspartic Acid, Biotin, Calcium Gluconate, Caprylyl Glycol, Chamomilla Recutita (Matricaria) Flower Extract, Ethylhexylglycerin, Gluconolactone, Glycine, Hexylene Glycol, Histidine, Hydrolyzed Glycosaminoglycans, Hydroxyethylcellulose, Isoleucine, Sodium Lactate, Magnesium Ascorbyl Phosphate, Panax Ginseng Root Extract, PCA, Valine, Phenylalanine, Polydextrose, Polysorbate 20, Proline, Propylene Glycol, Serine, Vitis Vinifera (Grape) Seed Extract, Sodium Hyaluronate, Isopropyl Cloprostenate, Yeast Extract, Sodium PCA, Threonine, Tocopheryl Acetate, Triethanolamine, Phenoxyethanol, Sodium Benzoate, Sodium Metabisulfite. Source:https://cdn.shopify.com/s/files/1/2460/2627/files/2022_BabeOriginal_Mobile_FullWarnings-Ingredients_f4ee9a0a-5b20-4dc7-b9a6-85ab031040d4.pdf?v=1655400590
Uklash Serum	Yes	Isopropyl Cloprostenate	Aqua, Glycerin, Butylene Glycol, Propanediol, 1,2-Hexanediol, Biotinoyl Tripeptide-1, Camellia Sinensis Leaf Extract, Caprylyl Glycol, Centella Asiatica Extract, Chamomilla Recutita Flower Extract, Ethylhexylglycerin, Glycyrrhiza Glabra Root Extract, Isopropyl Cloprostenate, Myristoyl Pentapeptide-17, Panthenol, Polygonum Cuspidatum Root Extract, Rosmarinus Officinalis Leaf Extract, Scutellaria Baicalensis Root Extract, Tocopherol, Xanthan Gum, Benzoic Acid, Phenoxyethanol, Sodium Benzoate Source: https://www.uklash.com/products/eyelash-serum

Bimatoprost is not the only prostaglandin analog you can find! When analyzing the ingredient list, you can find synthetic prostaglandin compounds such as:

• Isopropyl cloprostenate
• Isopropyl phenyl hydroxypentane
• Dihydroxy cyclopentyl heptane
• Dechloro dihydroxy difluoro ethylcloprostenolamide

So it’s important to be aware of these other names when reading the label.

Lash Serums Without Prostaglandins

• Lash Luxury
• LASHFOOD Serum
• Adoreeye lash serum
• Vegamour GRO lash serum
• The Ordinary lash serum
• Forever Lash
• Velour Lash Serum
• ForLash Serum

Most of these serums are peptides-based which means they stimulate the growth of your own lashes by promoting the production of keratin. Most of these serums will support your eyelashes during the 3 phases of the growth cycle:

• Anagen (active growth phase)
• Catagen (transition phase)
• Telogen (resting phase)

Yes, they have fewer clinical studies to back them up. However, they are much less likely to cause side effects. At the end of the day, you have to make the decision and accept the risks that come with it.

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